Oxford’s Vaccine Development Sees Progress


The vaccine candidate, ChAdOx1 nCoV-19, is currently being tested in humans too. Over 1,000 volunteers have participated in the clinical trials.

The results of the trial in six rhesus macaque monkeys were posted on Thursday at the preprint repository bioRxiv.

Rhesus macaque monkeys are considered to be good proxies for how drugs could work in humans as their immune systems are similar, but there is not guarantee that the results would replicate in people.

The researchers found that compared to those monkeys who got exposed to the virus that causes COVID-19 but did not receive the vaccine, the monkeys which received the vaccine had less of the virus in their lungs and airways.

The results showed that the ChAdOx1 nCoV-19 vaccination appears to prevent SARS-CoV-2 pneumonia in rhesus macaques.

Oxford University. by .

Researchers from the US government’s National Institutes of Health (NIH) and from the University of Oxford conducted the trial in the US, the BBC reported.

The researchers at Oxford University who have begun testing their potential vaccine against COVID-19 on a small group of human volunteers also hope to expand the tests soon after getting positive results from the initial trial.

The vaccine candidate for COVID-19 was identified by researchers from the Oxford Vaccine Group and Oxford’s Jenner Institute. The potential upcoming vaccine, ChAdOx1 nCoV-19, is based on an adenovirus vaccine vector and the SARS-CoV-2 spike protein.

By vaccinating with ChAdOx1 nCoV-19, the scientists hope to make the body recognise and develop an immune response to the Spike protein that will help stop the SARS-CoV-2 virus from entering human cells and therefore prevent infection.

Over 100 experimental COVID-19 vaccines are currently in different stages of development.

COVID-19 vaccine in 1 month? CSIR pins hope on Sepsivac by .
COVID-19 vaccine in 1 month? CSIR pins hope on Sepsivac

London reports drop in cases

London could be “coronavirus free” by June, as new modelling has suggested that the UK capital was recording only 24 new cases a day, according to an analysis by the Cambridge University and Public Health England published on Friday.

The ‘R’ reproduction rate has fallen to 0.4 in London, with the number of new cases halving every 3.5 days, the Metro newspaper quoted the analysis as saying.

London was initially the hub of the pandemic in the UK and was considered to be weeks ahead of the rest of the country.

When the lockdown was imposed on March 23 it was being hit by around 200,000 new cases per day, but the new modelling suggested that it could be free of fresh diagnoses by next month.

But social distancing concerns were raised after pictures emerged this week of packed London Underground trains with many passengers not wearing masks.

Despite the analysis, a professor at the London School of Hygiene and Tropical Medicine warned that London’s true infection rate was likely to be “a little bit higher”, the Metro newspaper reported.

LONDON, April 18, 2020 (Xinhua) -- A woman walks past a closed shop on Camden High Street in London, Britain, April 17, 2020. Another 847 people who tested positive for COVID-19 have died in hospitals in Britain as of Thursday afternoon, bringing the total number of coronavirus-related deaths to 14,576, the Department of Health and Social Care said Friday. (Photo by Tim Ireland/Xinhua/IANS) by .
A woman walks past a closed shop on Camden High Street in London. (Photo by Tim Ireland/Xinhua/IANS)

Speaking to the BBC Radio 4, he said: “There is some variation around this and there is some uncertainty in this, but what we have observed in London is that case numbers and death numbers have come down faster than in other parts of the country e albeit from a considerably higher level.

“So I think ite well, I would say it is a little bit higher than that, but it is probably lower than the rest of the country.”

As of Friday, the number of COVID-19 cases in the UK has increased to 234,441, with 33,693 deaths, the current highest in Europe.

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